An Immunoserological Study of Vaccine Against Haemorrhagic Fever with Renal Syndrome
Journal of the Korean Society of Virology
; : 11-18, 2000.
Article
em Ko
| WPRIM
| ID: wpr-160581
Biblioteca responsável:
WPRO
ABSTRACT
Since HantavaxTM, formalin inactivated Hantaan virus vaccine (10,240 ELISA units/ml), has been developed in 1990 to prevent against haemorrhagic fever with renal syndrome (HFRS) caused by Hantaan or Seoul virus, it has been commercially available in Korea. Twenty-one healthy people were booster shot once and twice after primary basic vaccination with HantavaxTM. Seroconversion rates were measured by immunofluorescent antibody technique (IFAT), enzyme-linked immunosorbent assay (ELISA), high density composite particle agglutination (HDPA), and plaque reduction neutralization test (PRNT). Seroconversion rates of 21 vaccinees at one year after primary basic vaccination were 52.3%, 95.2%, 0.0%, 47.6%, and 28.6%, and 13 vaccinees of one month after 1st booster vaccination were 100%, 100%, 30.7%, 100% and 100% by IFAT, ELISA (IgG, IgM), HDPA and PRNT, respectively. Seroconversion rates declined slightly by twenty months, and they were 84.6%, 92.3%, 0.0%, 84.6% and 69.2% by IFAT, ELISA (IgG, IgM), HDPA and PRNT, respectively. Seroconversion rates of 9 vaccinees at three months after 2nd booster vaccination were 100%, 100%, 0.0%, 100%, and 88.9%, and 16 vaccinees at one year after the 2nd booster vaccination were 87.5%, 93.8%, 0.0%, 87.5% and 81.3% by IFAT, ELISA (IgG, IgM), HDPA and PRNT, respectively. Based on the above result HantavaxTM has proved a vigorous anamnestic response after the 1st and the 2nd booster vaccination and has persisted higher fluorescence, agglutination and neutralizing antibody titers in vaccinees.
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Índice:
WPRIM
Assunto principal:
Ensaio de Imunoadsorção Enzimática
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Testes de Neutralização
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Vacinação
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Vírus Hantaan
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Vírus Seoul
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Aglutinação
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Anticorpos Neutralizantes
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Febre
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Fluorescência
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Formaldeído
País/Região como assunto:
Asia
Idioma:
Ko
Revista:
Journal of the Korean Society of Virology
Ano de publicação:
2000
Tipo de documento:
Article