Capsanthin Inhibits both Adipogenesis in 3T3-L1 Preadipocytes and Weight Gain in High-Fat Diet-Induced Obese Mice
Biomolecules & Therapeutics
;
: 329-336, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-160696
ABSTRACT
Adipogenesis in murine preadipocyte 3T3L-1 has been used as a model system to study anti-obese bioactive molecules. During adipogenesis in 3T3-L1 preadipocytes, we found that capsanthin inhibited adipogenesis (IC₅₀; 2.5 μM) and also showed lipolytic activity in differentiated adipocytes from the preadipocytes (ED₅₀ ; 872 nM). We identified that the pharmacological activity of capsanthin on adipogenesis in 3T3-L1 was mainly due to its adrenoceptor-β2-agonistic activity. In high-fat diet animal model study, capsanthin significantly enhanced spontaneous locomotive activities together with progressive weight-loss. The capsanthin-induced activation of kinetic behavior in mice was associated with the excessive production of ATP initiated by both the enhanced lipolytic activity together with accelerated oxidation of fatty acids due to the adrenoceptor β2-agonistic activity of capsanthin. Capsanthin also dose-dependently increased adiponectin and p-AMPK activity in high fat diet animals, suggesting that capsanthin has both anti-obesity and insulin sensitizing activities.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Aumento de Peso
/
Trifosfato de Adenosina
/
Adipócitos
/
Modelos Animais
/
Adiponectina
/
Adipogenia
/
Ácidos Graxos
/
Dieta Hiperlipídica
/
Insulina
/
Camundongos Obesos
Limite:
Animais
Idioma:
Inglês
Revista:
Biomolecules & Therapeutics
Ano de publicação:
2017
Tipo de documento:
Artigo
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