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Mantle cell lymphoma presented as multiple lymphomatous polyposis: clinical review of 4 cases / 대한내과학회지
Korean Journal of Medicine ; : 413-422, 2000.
Artigo em Coreano | WPRIM | ID: wpr-160743
ABSTRACT
Multiple lymphomatous polyposis(MLP) is an interesting clinical entity of non-Hodgkin's lymphoma(NHL) and is defined as B-cell lymphoma characterized by the presence of multiple lymphomatous polyps along the gastrointestinal tract. Recently MLP has been considered as a variant form of mantle cell lymphoma(MCL). The median survival of patients with MCL is only 3 years, and none of the available conventional chemotherapy regimens appears curative. Encouraging results have been reported with high dose chemotherapy with autoSCT and alloSCT for its treatment. We introduce 4 cases of MLP diagnosed as MCL by morphologic and immunologic method. The common clinical findings of these cases were splenomegaly (4/4), multiple intraabdominal lymphadenopathy (4/4), and advanced stage (3/4) at presentation. The overall remission duration was relatively short (5-27 months) and three of four cases relapsed after conventional chemotherapy or autologous stem cell transplant. Our report suggests that MCL presented as MLP is a high risk subgroup of NHL and more aggressive approach may be needed for cure.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pólipos / Esplenomegalia / Células-Tronco / Linfoma de Células B / Linfoma de Célula do Manto / Trato Gastrointestinal / Tratamento Farmacológico / Doenças Linfáticas / Linfoma Limite: Humanos Idioma: Coreano Revista: Korean Journal of Medicine Ano de publicação: 2000 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pólipos / Esplenomegalia / Células-Tronco / Linfoma de Células B / Linfoma de Célula do Manto / Trato Gastrointestinal / Tratamento Farmacológico / Doenças Linfáticas / Linfoma Limite: Humanos Idioma: Coreano Revista: Korean Journal of Medicine Ano de publicação: 2000 Tipo de documento: Artigo