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An Analysis for Angiotensin Converting Enzyme Gene Polymorphism in Formalin-fixed, Paraffin-embedded Tissues from Patients with Sarcoidosis
Korean Journal of Pathology ; : 225-231, 2003.
Artigo em Coreano | WPRIM | ID: wpr-161017
ABSTRACT

BACKGROUND:

Sarcoidosis is a systemic disease characterized by nonnecrotizing granulomas involving the lung and hilar lymph nodes. Serum angiotensin converting enzyme (sACE) levelsin patients with sarcoidosis have been implicated as an indicator of granuloma burden.Recently, it has been found that ACE gene insertion/deletion (ID) polymorphism affects sACE levels in healthy individuals. Moreover, reported sACE levels were highest in the deletion/deletion(DD) genotype. Previous studies to investigate the distribution of ACE genotypes accordingto ethnic groups have revealed various results and have caused controversy.

METHODS:

Polymerase chain reactions were performed to determine the ACE genotypes in fifteen formalinfixed, paraffin-embedded tissues from patients with sarcoidosis.

RESULTS:

The distribution of ACE gene (I/D) polymorphism in patients with sarcoidosis was significantly different from that in normal controls. The DD genotype was more frequent in patients with sarcoidosis than in thenormal controls. The D allele frequency was also higher in patients with sarcoidosis than in thenormal controls. The relative risk of sarcoidosis was higher in DD homozygotes.

CONCLUSIONS:

These results suggested the ACE gene I/D polymorphism may play an important rolein the pathogenesis and progression of sarcoidosis.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sarcoidose / Angiotensinas / Etnicidade / Reação em Cadeia da Polimerase / Peptidil Dipeptidase A / Frequência do Gene / Genótipo / Granuloma / Homozigoto / Pulmão Tipo de estudo: Estudo de etiologia Limite: Humanos Idioma: Coreano Revista: Korean Journal of Pathology Ano de publicação: 2003 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sarcoidose / Angiotensinas / Etnicidade / Reação em Cadeia da Polimerase / Peptidil Dipeptidase A / Frequência do Gene / Genótipo / Granuloma / Homozigoto / Pulmão Tipo de estudo: Estudo de etiologia Limite: Humanos Idioma: Coreano Revista: Korean Journal of Pathology Ano de publicação: 2003 Tipo de documento: Artigo