The relationship between serum adiponectin and inflammatory cytokines in obese Korean juveniles / 소아과
Korean Journal of Pediatrics
;
: 533-537, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-161258
ABSTRACT
PURPOSE:
Obesity is related to systemic inflammatory processes causing cardiovascular complications. Intercellular adhesion molecule-1 (ICAM-1), CD40 ligand (CD40L), P-selectin are newly described mediators of inflammation and have a significant effect in atherosclerosis. Adiponectin has shown anti-inflammatory effects in adults. The aim of this study was to evaluate the relationship between adiponectin and inflammatory mediators in children and adolescents.METHODS:
Fifty children or adolescents, twenty two with a body mass index (BMI) over 95th percentile, and twenty eight with a BMI below 75th percentile were included in the study. Serum soluble ICAM-1 (sICAM-1), P-selectin, CD40L, lipid profiles, aspartate aminotransferase, alanine aminotransferase, glucose and insulin were measured to evaluate associations with adiponectin. Comparison of these variables was performed between the obese and the nonobese group.RESULTS:
We found a adiponectin to be significant lower and sICAM-1 significant higher in the obese group compared to the nonobese group, but there were no significant differences in P-selectin and soluble CD40L. Adiponectin was negatively associated with ICAM-1 and P-selectin in the obese group.CONCLUSION:
Negative associations of adiponectin with ICAM-1 and P-selectin in obese children and adolescents suggest that serum adiponectin level may represent the inflammatory status.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Aspartato Aminotransferases
/
Índice de Massa Corporal
/
Citocinas
/
Molécula 1 de Adesão Intercelular
/
Mediadores da Inflamação
/
Selectina-P
/
Ligante de CD40
/
Alanina Transaminase
/
Aterosclerose
/
Adiponectina
Limite:
Adolescente
/
Adulto
/
Criança
/
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Pediatrics
Ano de publicação:
2014
Tipo de documento:
Artigo
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