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Detection of Malignant Primary Hepatic Neoplasms with Gadobenate Dimeglumine (Gd-BOPTA) Enhanced T1-Weighted Hepatocyte Phase MR Imaging: Results of Off-site Blinded Review in a Phase-II Multicenter Trial
Korean Journal of Radiology ; : 210-215, 2001.
Artigo em Inglês | WPRIM | ID: wpr-161552
ABSTRACT

OBJECTIVE:

To investigate the efficacy of gadobenate dimeglumine (Gd-BOPTA) enhanced MR imaging for the detection of liver lesions in patients with primary malignant hepatic neoplasms. MATERIALS AND

METHODS:

Thirty-one patients with histologically proven primary malignancy of the liver were evaluated before and after administration of Gd-BOPTA at dose 0.05 or 0.10 mmol/kg. T1-weighted spin echo (T1W-SE) and gradient echo (T1W-GRE) images were evaluated for lesion number, location, size and confidence by three off-site independent reviewers and the findings were compared to reference standard imaging (intraoperative ultrasound, computed tomography during arterial portography or lipiodol computed tomography). Results were analyzed for significance using a two-sided McNemar's test.

RESULTS:

More lesions were identified on Gd-BOPTA enhanced images than on unenhanced images and there was no significant difference in lesion detection between either concentration. The largest benefit was in detection of lesions under 1 cm in size (7 to 21, 9 to 15, 16 to 18 for reviewers A, B, C respectively). In 68% of the patients with more than one lesion, Gd-BOPTA increased the number of lesions detected.

CONCLUSION:

Liver MR imaging after Gd-BOPTA increases the detection of liver lesions in patients with primary malignant hepatic neoplasm.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Compostos Organometálicos / Imageamento por Ressonância Magnética / Aumento da Imagem / Adenoma de Células Hepáticas / Meios de Contraste / Neoplasias Hepáticas / Meglumina / Pessoa de Meia-Idade Tipo de estudo: Estudo diagnóstico / Estudo prognóstico Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Korean Journal of Radiology Ano de publicação: 2001 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Compostos Organometálicos / Imageamento por Ressonância Magnética / Aumento da Imagem / Adenoma de Células Hepáticas / Meios de Contraste / Neoplasias Hepáticas / Meglumina / Pessoa de Meia-Idade Tipo de estudo: Estudo diagnóstico / Estudo prognóstico Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Korean Journal of Radiology Ano de publicação: 2001 Tipo de documento: Artigo