Locally Advanced, Unresectable Pancreatic Cancer Treated by Stereotactic Radiation Therapy / 대한방사선종양학회지

ABSTRACT

PURPOSE: In order to find out whether stereotactic radiation therapy (RT) using CyberKnife (CK) could improve survival rate and lower acute toxicity compared to conventional RT. MATERIALS AND METHODS: From April 2003 through April 2004, 19 patients with Eastern Cooperative Oncology Group (ECOG) performance status 80 cc (p-value80 cc showed better survival rate. CONCLUSION: In terms of survival, the efficacy of stereotactic radiation therapy using CK was found to be superior or similar to other recent studies achieved with conventional RT with intensive chemotherapy, high dose conformal RT, intraoperative RT (IORT), or intensity modulated RT (IMRT). Furthermore, severe toxicity was not observed. Short treatment time in relation to the short life expectancy gave patients more convenience and, finally, quality of life would be increased. Consequently, this could be regarded as an effective novel treatment modality for locally advanced, unresectable pancreas cancer. PTV would be a helpful prognostic factor for CK.