Evaluation of Serum Cystatin C Concentration as a Marker of Renal Function in Liver Cirrhosis Patients / 대한신장학회지

ABSTRACT

PURPOSE: Cystatin C is known to predict the glomerular filtration rate (GFR) more precisely in patients with substantial muscle atrophy, such as liver cirrhosis, compared to creatinine. We evaluated the usefulness of cystatin C for prediction of renal function in liver cirrhosis patients. METHODS: From February 2007 to September 2007, we evaluated the renal function in patients with liver cirrhosis who were admitted to Soonchunhyang University Bucheon Hospital. We compared renal function with GFR as estimated by creatinine (Modification of diet in renal diseases; MDRD, the Cockroft&Gault equation; C&G, Creatinine clearance; CCr) and cystatin C (the Hoek and Larsson equations) with that of the GFR as calculated by Cr-EDTA. RESULTS: A total of 46 patients were enrolled. The mean GFR was 67.8+/-29.4, 81.6+/-29.6, 79.9+/-29.3, 62.7+/-29.8, 77.0+/-28.6, 81.0+/-35.2 mL/min/1.73m2 according to Cr-EDTA, MDRD, C&G, CCr, Hoek and Larsson equations, respectively. Cystatin C showed a correlation to MDRD (r=-0.715), C&G (r=-0.659), CCr (r=-0.536) and Cr-EDTA GFR (r=-0.617). GFR by the Hoek (r=0.657) and the Larsson (r=0.647) equation using cystatin C showed a higher correlation with Cr-EDTA GFR than GFR by MDRD (r=0.550) and C&G equation (r=0.458). CONCLUSION: Cystatin C is a more accurate predictor of renal function than creatinine in patients with liver cirrhosis.