Risk Factors for Osteoporotic Vertebral Fracture in Cushing Syndrome
Journal of Korean Society of Spine Surgery
;
: 1-6, 2017.
Artigo
em Coreano
| WPRIM
| ID: wpr-162087
ABSTRACT
STUDY DESIGN:
Retrospective study.OBJECTIVES:
The goal of this study was to evaluate the risk factors of osteoporotic vertebral fractures (OVFs) in patients with Cushing syndrome. SUMMARY OF LITERATURE REVIEW In most reports, vertebral fractures in Cushing syndrome have been found to be related to osteoporosis. However, few studies have analyzed the clinical risk factors for OVFs. MATERIALS ANDMETHODS:
Thirty-two patients with Cushing syndrome who visited the orthopaedic department complaining of back pain were included in this study. Standing lateral X-rays were performed to evaluate the presence of vertebral fractures, and bone mineral density (BMD) was measured.RESULTS:
Of the 32 patients with Cushing syndrome with back pain, 8 (25%) were diagnosed with OVFs using morphometric criteria. The average weight and body mass index of the vertebral fracture group (VF group) were significantly higher than the values observed in the non-vertebral fracture group (non-VF group) (p=0.004, p=0.018). Lumbar BMD was significantly lower in the VF group (p=0.006). A risk factor for OVFs in Cushing syndrome was osteoporosis (odds ratio=18.56, 95% confidence interval=1.72-200.21, p=0.016) regardless of gender, obesity, menopause, or urine free cortisol levels.CONCLUSIONS:
OVFs in Cushing syndrome have been associated with overweight, and overweight is an indicator of compliance in the treatment of Cushing syndrome. Therefore, weight reduction and the prevention of osteoporosis should be emphasized in patients with Cushing syndrome to prevent OVFs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoporose
/
Menopausa
/
Hidrocortisona
/
Redução de Peso
/
Índice de Massa Corporal
/
Densidade Óssea
/
Estudos Retrospectivos
/
Fatores de Risco
/
Dor nas Costas
/
Complacência (Medida de Distensibilidade)
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Journal of Korean Society of Spine Surgery
Ano de publicação:
2017
Tipo de documento:
Artigo
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