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A Winged-Helix Transcription Factor Foxg1 Induces Expression of Mss4 Gene in Rat Hippocampal Progenitor Cells
Experimental Neurobiology ; : 75-82, 2010.
Artigo em Inglês | WPRIM | ID: wpr-162262
ABSTRACT
Foxg1 (previously named BF1) is a winged-helix transcription factor with restricted expression pattern in the telencephalic neuroepithelium of the neural tube and in the anterior half of the developing optic vesicle. Previous studies have shown that the targeted disruption of the Foxg1 gene leads to hypoplasia of the cerebral hemispheres with severe defect in the structures of the ventral telencephalon. To further investigate the molecular mechanisms by which Foxg1 plays essential roles during brain development, we have adopted a strategy to isolate genes whose expression changes immediately after introduction of Foxg1 in cultured neural precursor cell line, HiB5. Here, we report that seventeen genes were isolated by ordered differential displays that are up-regulated by over-expression of Foxg1, in cultured neuronal precursor cells. By nucleotide sequence comparison to known genes in the GeneBank database, we find that nine of these clones represent novel genes whose DNA sequences have not been reported. The results suggest that these genes are closely related to developmental regulation of Foxg1.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Células-Tronco / Telencéfalo / Fatores de Transcrição / Encéfalo / Sequência de Bases / Linhagem Celular / Células Clonais / Cérebro / Tubo Neural / Neurônios Limite: Animais Idioma: Inglês Revista: Experimental Neurobiology Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Células-Tronco / Telencéfalo / Fatores de Transcrição / Encéfalo / Sequência de Bases / Linhagem Celular / Células Clonais / Cérebro / Tubo Neural / Neurônios Limite: Animais Idioma: Inglês Revista: Experimental Neurobiology Ano de publicação: 2010 Tipo de documento: Artigo