Neurotoxic Effects of Tetrahydroisoquinolines and Underlying Mechanisms
Experimental Neurobiology
;
: 63-70, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-162264
ABSTRACT
Tetrahydropapaveroline (THP), a neurotoxic tetrahydroisoquinoline alkaloid formed by condensation between dopamine and dopaldehyde, has been speculated to cause Parkinson's disease and also to contribute to alcohol dependence. Having two catechol moieties, THP may readily undergo oxidation to form an o-quinone intermediate with concomitant production of reactive oxygen species, which can cause neuronal cell death and DNA damage. This review will deal with the current knowledge of neurotoxic effects of this endogenous alkaloid and underlying biochemical mechanisms.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Tetra-Hidropapaverolina
/
Dano ao DNA
/
Dopamina
/
Catecóis
/
Morte Celular
/
Espécies Reativas de Oxigênio
/
Tetra-Hidroisoquinolinas
/
Alcoolismo
/
Neurônios
Idioma:
Inglês
Revista:
Experimental Neurobiology
Ano de publicação:
2010
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS