Concurrence of Membranous Glomerulonephritis and Pulmonary Alveolar Proteinosis / 대한내과학회지
Korean Journal of Medicine
;
: 215-218, 2014.
Artigo
em Coreano
| WPRIM
| ID: wpr-162310
ABSTRACT
Membranous glomerulonephritis is one of the most common causes of nephrotic syndrome in adults. Pulmonary alveolar proteinosis (PAP) is a rare lung disease in which abnormal accumulation of surfactant occurs within the alveoli. We describe a 61-year-old man with concurrent membranous glomerulonephritis and PAP, which is very rare; both are pathophysiologically related to an abnormal immune response. A patient came to hospital with leg edema but no respiratory symptoms. Chest X-ray and CT showed classical PAP findings, which are ground-glass opacities with interlobular septal thickening, in both lung fields. A bubbly whitish secretion retrieved via broncho-alveolar lavage showed neutrophils and lymphocytes as well as Periodic acid-Schiff-positive proteinaceous materials. A kidney biopsy revealed findings of membranous glomerulonephritis with irregular subepithelial deposits by electron microscopy. At 1 year after diagnosis, the membranous glomerulonephritis was well under control with steroids and mycophenolate mofetil but PAP became aggravated gradually and whole-lung lavage was needed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteinose Alveolar Pulmonar
/
Esteroides
/
Tórax
/
Biópsia
/
Linfócitos
/
Microscopia Eletrônica
/
Glomerulonefrite Membranosa
/
Diagnóstico
/
Edema
/
Irrigação Terapêutica
Tipo de estudo:
Estudo diagnóstico
Limite:
Adulto
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Ano de publicação:
2014
Tipo de documento:
Artigo
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