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Oxaliplatin with Biweekly, Low Dose Leucovorin and Bolus and Continuous Infusion 5-fluorouracil (Modified FOLFOX 4) as First-line Therapy for Patients with Metastatic Colorectal Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 115-120, 2004.
Artigo em Inglês | WPRIM | ID: wpr-162444
ABSTRACT

PURPOSE:

To determine the activity and toxicities of low dose leucovorin (LV) plus fluorouracil (5-FU) regimen, combined with oxaliplatin every two weeks (modified FOLFOX 4), as a first-line therapy for patients with metastatic colorectal cancer. MATERIALS AND

METHODS:

Between March 2001 and August 2003, fifty-five patients were enrolled in this study. Patients were treated with oxaliplatin 85 mg/m2 as a 2-hour infusion at days 1 plus LV 20 mg/m2 over 10 minutes, followed by 5-FU bolusa 400 mg/m2 bolus and 22 hour continuous infusion of 600 mg/m2 5-FU at day 1~2. This treatment was repeated in 2 week intervals.

RESULTS:

The objective response rate was 40% on an intent-to-treatment analysis. Three patients (6%) demonstrated a complete response and nineteen patients (38%) showeda partial response. Sixteen patients (32%) showed a stable disease and eleven patients (22%) progressed during the course of the treatment. The median time to progression and overall survival time wereas 6.6 months (95% CI 4.98~8.02 months) and the median overall survival time was 17.0 months (95% CI 9.15~24.85 months) from the start of the chemotherapy, respectively. A total of 275 cycles were analyzed for toxicity. Major hematologic toxicities included grade 1~2 anemia (23.5%), neutropenia (25.3%) and thrombocytopenia (10.6%). There were only 2 cycles of neutropenic fever. The most common non- hematologic toxicities were grade 1~2 nausea/vomiting (10.9%), diarrhea (9.1%) and grade 1 neuropathy (18.0%). There was no treatment related death.

CONCLUSION:

The modified folfox 4 regimen is safe and effective regimen as a first-line therapy in advanced colorectal cancer patients.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Trombocitopenia / Neoplasias Colorretais / Leucovorina / Diarreia / Tratamento Farmacológico / Febre / Fluoruracila / Anemia / Neutropenia Limite: Humanos Idioma: Inglês Revista: Cancer Research and Treatment Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Trombocitopenia / Neoplasias Colorretais / Leucovorina / Diarreia / Tratamento Farmacológico / Febre / Fluoruracila / Anemia / Neutropenia Limite: Humanos Idioma: Inglês Revista: Cancer Research and Treatment Ano de publicação: 2004 Tipo de documento: Artigo