Effects of artesunate in the cobination of other antimalarial drugs on activities of some murine plasma enzymes

ABSTRACT

Effects of artesunate in the combination of other antimalarial drugs (primaquine, mefloquine or chloroquine) on activities of some murine plasma enzymes were studied (1) The combination of artesunate with primaquine induced significantly plasma activities of GOT, GPT, LDH, - HBDH, CK and CK- MB in comparison with artesunate alone; (2) The combination of artesunate with mefloquine also induced significantly plasma activities of GOT, GPT, LDH, -HBDH, CK and CK- MB in comparison with artesunate alone; (3) The companation of artesunate with chloroquine reduced slightly plasma activities of GOT, GPT, LDH, -HBDH, CK and CK-MB. The results obtained in the study suggest that the combination of artesunate with primaquine or mefloquine on murine cellular damage is synergistic, while the combination of artesunate with chloroquine is probably antagonistic