Effects of AII Receptor Blocker on the Urinary Excretion of IL-6 and TGF-beta in IgA Nephropathy / 대한신장학회잡지
Korean Journal of Nephrology
;
: 407-413, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-162516
ABSTRACT
BACKGROUND:
Urinary levels of cytokines may function as indices of renal disease activity.METHODS:
This study was designed to investigate the urinary excretion of IL-6 and TGF-beta in the patients with IgA nephropathy(IgAN) and the effects of AII receptor blockers(ARB losartan) on it.RESULTS:
The patients with IgAN(n=10) showed higher urinary excretion of IL-6 and TGF-beta than normal controls(n=7). There is a positive correlation between IL-6 and TGF-beta. Urinary excretion of IL- 6 was positively correlated with proteinuria in IgAN (IL-6 gamma2=0.560; p < 0.05) but not with serum creatinine. After 2 months of ARB therapy in IgAN patients, urinary excretion of IL-6 was decreased(IL-6 11.3+/-7.7 vs 5.3+/-3.3 pg/mg Cr, p < 0.05). Positive correlations were noticed in ARB group between urinary cytokines and proteinuria.CONCLUSION:
Our data suggest that the patients with IgAN showed higher urinary excretion of IL-6 and TGF-beta. and the IL-6 excretion can be effectively reduced by ARB therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteinúria
/
Imunoglobulina A
/
Citocinas
/
Fator de Crescimento Transformador beta
/
Interleucina-6
/
Creatinina
/
Glomerulonefrite por IGA
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Nephrology
Ano de publicação:
2002
Tipo de documento:
Artigo
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