Hepatic Septal Fibrosis Induced by Long-term Use of Ketoconazole / 대한간학회지
The Korean Journal of Hepatology
;
: 241-245, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-16286
ABSTRACT
Ketoconazole, an imidazole derivative, is a broad spectrum antifungal agent which has been used widely in the treatment of systemic or local fungal infections. Mild asymptomatic elevation of plasma transaminase activities occurs in approximately 6% to 17.5% of patients who have used ketoconazole. However, the incidence of symptomatic hepatic injury is low and overt hepatitis develops in about 5% of the patients. Nausea and vomiting are the most frequent side reactions. Histopathological features of the reported ketoconazole induced hepatotoxicity are massive or submassive hepatocellular necrosis involving the acinar zone 3, destroyed lobular architecture with bridging necrosis and inflammatory cell infiltration on portal tracts. However, hepatic septal fibrosis with liver cirrhosis has not been reported yet. We experienced a case of hepatic septal fibrosis that developed after 9 months of ketoconazole administration.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Vômito
/
Fibrose
/
Incidência
/
Hepatite
/
Cetoconazol
/
Cirrose Hepática
/
Náusea
/
Necrose
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Hepatology
Ano de publicação:
2000
Tipo de documento:
Artigo
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