Dopamine Transporter Density of the Basal Ganglia in Children with Attention Deficit Hyperactivity Disorder Assessed with I-123 IPT SPECT / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 95-103, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-162865
ABSTRACT
OBJECTIVE:
ADHD has been known as a psychiatric disorder in childhood associated with dopamine dysregulation. In the present study, we investigated dopamine transporter (DAT) density using I-123N-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane (I-123-IPT)-SPECT in children with ADHD on the hypothesis that alterations of DAT density in the basal ganglia were suggestive of dopaminergic dysfunction in children with ADHD.METHODS:
Nine drug-naive children with ADHD and six normal children were included in the study. We performed brain SPECT two hours after the intravenous administration of I-123-IPT and made both quantitative and qualitative analyses using the obtained SPECT data, which were reconstructed for the assessment of specific/nonspecific DAT binding ratios in the basal ganglia. We then investigated the correlation between ADHD Rating Scale (ARS) scores of children with ADHD and specific/nonspecific DAT binding ratios in the basal ganglia.RESULTS:
Children with ADHD had significantly greater specific/nonspecific DAT binding ratio of the basal ganglia comparing to normal children. However, no significant correlation were found between ARS scores of children with ADHD and specific/nonspecific DAT binding ratio of basal ganglia in children with ADHD.CONCLUSION:
These findings support the complex dysregulation of the dopaminergic neurotransmitter system in children with ADHD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transtorno do Deficit de Atenção com Hiperatividade
/
Gânglios da Base
/
Encéfalo
/
Dopamina
/
Tomografia Computadorizada de Emissão de Fóton Único
/
Neurotransmissores
/
Proteínas da Membrana Plasmática de Transporte de Dopamina
/
Administração Intravenosa
Tipo de estudo:
Pesquisa qualitativa
Limite:
Criança
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Psychopharmacology
Ano de publicação:
2002
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS