Aspergillus oryzae S-03 Produces Gingipain Inhibitors as a Virulence Factor for Porphyromonas gingivalis
Journal of Bacteriology and Virology
;
: 152-161, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-163002
ABSTRACT
Oral infection with Porphyromonas (P.) gingivalis causes periodontitis that is manifested by the destruction of gingival connective tissues. Although a few types of antibiotics are effective against the infection, its use induces the appearance of drug-resistant bacteria. The present study shows that the fermented product of Aspergillus (A.) oryzae S-03, cultivated on the fat-removed soybean, inhibits the cell growth of the P. gingivalis. Likewise, the fermented product of the S-03 strain cultured for 26~42 h displays an inhibitory activity to gingipain as a virulence factor of P. gingivalis. The activity is not lost even with heat treatment at 100degrees C for 15 min. We also demonstrate that the S-03 strain exhibits high protease activity. In addition, the strain does not produce aflatoxin because of the loss of a regulatory gene, aflR, necessary for the toxin biosynthesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Periodontite
/
Aspergillus
/
Aspergillus oryzae
/
Oryza
/
Glycine max
/
Bactérias
/
Virulência
/
Genes Reguladores
/
Porphyromonas
/
Porphyromonas gingivalis
Idioma:
Inglês
Revista:
Journal of Bacteriology and Virology
Ano de publicação:
2014
Tipo de documento:
Artigo
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