Tranexamic Acid Diminishes Laser-Induced Melanogenesis
Annals of Dermatology
;
: 250-256, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-163405
ABSTRACT
BACKGROUND:
The treatment of post-inflammatory hyperpigmentation (PIH) remains challenging. Tranexamic acid, a well-known anti-fibrinolytic drug, has recently demonstrated a curative effect towards melasma and ultraviolet-induced PIH in Asian countries. However, the precise mechanism of its inhibitory effect on melanogenesis is not fully understood.OBJECTIVE:
In order to clarify the inhibitory effect of tranexamic acid on PIH, we investigated its effects on mouse melanocytes (i.e., melan-a cells) and human melanocytes.METHODS:
Melan-a cells and human melanocytes were cultured with fractional CO2 laser-treated keratinocyte-conditioned media. Melanin content and tyrosinase activity were evaluated in cells treated with or without tranexamic acid. Protein levels of tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 were evaluated in melan-a cells. Signaling pathway molecules involved in melanogenesis in melanoma cells were also investigated.RESULTS:
Tranexamic acid-treated melanocytes exhibited reduced melanin content and tyrosinase activity. Tranexamic acid also decreased tyrosinase, TRP-1, and TRP-2 protein levels. This inhibitory effect on melanogenesis was considered to be involved in extracellular signal-regulated kinase signaling pathways and subsequently microphthalmia-associated transcription factor degradation.CONCLUSION:
Tranexamic acid may be an attractive candidate for the treatment of PIH.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosfotransferases
/
Ácido Tranexâmico
/
Monofenol Mono-Oxigenase
/
Hiperpigmentação
/
Povo Asiático
/
Fator de Transcrição Associado à Microftalmia
/
Antígeno MART-1
/
Melaninas
/
Melanócitos
/
Melanoma
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Annals of Dermatology
Ano de publicação:
2015
Tipo de documento:
Artigo
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