Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus
Annals of Pediatric Endocrinology & Metabolism
;
: 69-73, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-163415
ABSTRACT
Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the local IGF-I-IGFBPs environment in response to the diabetic milieu. A significant reduction of serum IGF-I levels was observed in patients with type 1 diabetes mellitus (T1DM). Inversely, considerably increased serum levels of IGF-I and IGFBP-3 levels were detected in individuals with glucose intolerance including T2DM. Recently, several prospective studies indicated that baseline levels of IGF-I and IGFBPs are associated with the development of diabetes. These findings suggest that disturbances in insulin and IGF-I-IGFBP axis can affect the development of glucose intolerance including diabetes.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Vértebra Cervical Áxis
/
Fator de Crescimento Insulin-Like I
/
Proteínas de Transporte
/
Intolerância à Glucose
/
Proteínas de Ligação a Fator de Crescimento Semelhante a Insulina
/
Proteína 1 de Ligação a Fator de Crescimento Semelhante à Insulina
/
Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina
/
Diabetes Mellitus
/
Diabetes Mellitus Tipo 1
/
Metabolismo dos Lipídeos
Tipo de estudo:
Estudo observacional
Limite:
Humanos
Idioma:
Inglês
Revista:
Annals of Pediatric Endocrinology & Metabolism
Ano de publicação:
2015
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS