Expression of Neuropeptides and Their Receptors in Melasma / 대한피부과학회지
Korean Journal of Dermatology
;
: 627-632, 2008.
Artigo
em Coreano
| WPRIM
| ID: wpr-163671
ABSTRACT
BACKGROUND:
The pathogenesis of melasma has not yet been clearly demonstrated. But, clinical manifestations such as remarkable lesional symmetry and the distribution related to trigeminal nerves, suggest that the neural system could play a pathogenic role in melasma.OBJECTIVE:
This study was carried out to examine the expression of some neuropeptides and their receptors, which are well known to be major contributors of neuroinflammation in many dermatoses, in melasma lesions.METHODS:
Skin biopsies were obtained from the lesional and non-lesional facial skin of 6 Korean women with melasma. Immunofluorecence staining and confocal laser scanning microscopy were performed.RESULTS:
In our results, no difference could be detected with regard to the intensity of immunoreactivity for vasoactive intestinal peptide (VIP), calcitonin gene-related peptide (CGRP), calcitonin gene-related peptide receptor (CGRPR), substance P (SP), substance P receptor (SPR), somatostatin (SOM), pituitary adenylate cyclase activating peptide (PACAP) and pituitary adenylate cyclase activating peptide receptor (PACAPR) in the lesional skins compared with the non-lesional skins.CONCLUSION:
These results suggest that neuroinflammation induced by neuropeptides such as substance P, calcitonin gene-related peptide, vasoactive intestinal peptide, and somatostatin and their receptors included in this study, are not directly associated with melasma pathogenesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
Dermatopatias
/
Nervo Trigêmeo
/
Biópsia
/
Neuropeptídeos
/
Somatostatina
/
Peptídeo Intestinal Vasoativo
/
Substância P
/
Peptídeo Relacionado com Gene de Calcitonina
/
Adenilil Ciclases
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
2008
Tipo de documento:
Artigo
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