Antigenicity of the G2 Glycoprotein in Cell - Mediated Immune Response Against Hantanvirus Infection
Journal of the Korean Society for Microbiology
;
: 619-624, 1998.
Artigo
em Coreano
| WPRIM
| ID: wpr-164096
ABSTRACT
Hemorrhagic fever with renal syndrom is an acute febrile disease which is caused by Hantanvirus and several other viruses that belong to the genus Hantavirus. Gl and G2 glycoproteins of Hantanvirus have been thought to be involved in protective immunity against Hantanvirus infection. In this study, the antigenicity of G1 and G2 glycoproteins in cell mediated immune response was investigated. When peripheral blood mononuclear cell fraction from recovered hemorrhagic fever with renal syndrome patient was cultivated with a recombinant protein containing amino-terminal 78 amino acids of G2 glycoprotein, these cells were activated to proliferate and secreted significant amount of interleukin-2 and interferon-r. These results suggest that T cell epitope exists in the amino-terminal region of G2 glycoprotein.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Glicoproteínas
/
Interleucina-2
/
Orthohantavírus
/
Epitopos de Linfócito T
/
Febre
/
Aminoácidos
/
Febre Hemorrágica com Síndrome Renal
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Society for Microbiology
Ano de publicação:
1998
Tipo de documento:
Artigo
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