Study on the Factor V Leiden Mutation in Pregnant Women and Relationship with Preeclampsia Severe Form / 대한주산의학회잡지
Korean Journal of Perinatology
;
: 406-412, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-164146
ABSTRACT
OBJECTIVE:
A study showed that resistance to activated protein C may develope some cases of severe preeclampsia. A common missense mutation in the factor V gene, the Leiden mutation, is the most frequent genetic cause of resistance to activated protein C. Our objective was to determine whether this mutation is more prevalent in patients with severe preeclampsia than in normotensive controls.METHOD:
Deoxyribonucleic acid was extracted from whole blood of 158 gravid women of severe preeclampsia and 403 normotensive gravid women. The polymerase chain reaction was used to amplify exon 10 of the factor V gene, followed by allele-specific restriction with Mnl 1 for mutation detection.RESULTS:
No patients were homozygous for the Leiden mutation. We could not find any positive case with FVQ506 in the normal or patient group.CONCLUSION:
We could not find that carriers of the factor V Leiden mutation are increased risk for severe preeclampsia. In contrast to the reports in Caucasian, the prevalence of APC resistance and FVQ506 might be very low or absent in the Korean population. But, carriers of this common thrombophilic mutation may be identified so that other causes and risk factors for inherited thrombophilia should be investigated in the Korean population.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pré-Eclâmpsia
/
DNA
/
Fator V
/
Proteína C
/
Reação em Cadeia da Polimerase
/
Éxons
/
Prevalência
/
Fatores de Risco
/
Trombofilia
/
Resistência à Proteína C Ativada
Tipo de estudo:
Estudo de etiologia
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Perinatology
Ano de publicação:
2002
Tipo de documento:
Artigo
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