Clinical Features of Drug-induced Liver Injury According to Etiology
Journal of Korean Medical Science
;
: 1815-1820, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-164153
ABSTRACT
Drug-induced liver injury (DILI) is an increasingly common cause of acute hepatitis. We examined clinical features and types of liver injury of 65 affected patients who underwent liver biopsy according DILI etiology. The major causes of DILI were the use of herbal medications (43.2%), prescribed medications (21.6%), and traditional therapeutic preparations and dietary supplements (35%). DILI from herbal medications, traditional therapeutic preparations, and dietary supplements was associated with higher elevations in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels than was DILI from prescription medications. The types of liver injury based on the R ratio were hepatocellular (67.7%), mixed (10.8%), and cholestatic (21.5%). Herbal medications and traditional therapeutic preparations were more commonly associated with hepatocellular liver injury than were prescription medications (P = 0.002). Herbal medications and traditional therapeutic preparations induce more hepatocellular DILI and increased elevations in AST and ALT than prescribed medications.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Aspartato Aminotransferases
/
Estudos Retrospectivos
/
Suplementos Nutricionais
/
Preparações de Plantas
/
Alanina Transaminase
/
Medicamentos sob Prescrição
/
Doença Hepática Induzida por Substâncias e Drogas
/
República da Coreia
/
Fitoterapia
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2015
Tipo de documento:
Artigo
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