Evaluation of Arterial Stiffness in Patients with Behcet's Disease by Using Noninvasive Radiological Methods such as Intima-Media Thickness of the Carotid, Ankle-Brachial Pressure Index, Coronary Artery Calcium Scoring, and Their Relation to Serum Fetuin-
Annals of Dermatology
;
: 702-708, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-164336
ABSTRACT
BACKGROUND:
Behcet's disease (BD) is a chronic, recurrent inflammatory systemic vasculitis. Evidence for increased atherosclerosis in BD has been observed. The relation between cardiovascular risk factors and increased atherosclerosis in patients with BD is still controversial.OBJECTIVE:
We performed this study to evaluate arterial stiffness in patients with BD by using noninvasive radiological methods such as carotid artery intima-media thickness (CIMT), ankle-brachial pressure index (ABPI), coronary artery calcium score (CACaS), and their relation to serum fetuin-A levels, which was recently found to be important in vascular calcification.METHODS:
This prospective study included 26 patients with BD and 25 control subjects. In all patients, the CIMT, ABPI, CACaS, and serum fetuin-A levels were examined.RESULTS:
The CIMT and CACaS were statistically higher and the ABPI was statistically lower in BD patients than in the control group. All p-values were <0.001. Positive correlations were found between the CACaS and CIMT, and negative correlations were found between the CACaS and ABPI. Although the values of fetuin-A were higher in BD, the difference was not statistically significant (p=0.064). However, the correlations found between fetuin-A levels and CIMT and between fetuin-A levels and CACaS were significant.CONCLUSION:
The CIMT, CACaS, and ABPI are all useful in detecting structural and functional vascular damage in BD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças Cardiovasculares
/
Artérias Carótidas
/
Estudos de Casos e Controles
/
Cálcio
/
Estudos Prospectivos
/
Fatores de Risco
/
Vasos Coronários
/
Aterosclerose
/
Índice Tornozelo-Braço
/
Vasculite Sistêmica
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Annals of Dermatology
Ano de publicação:
2015
Tipo de documento:
Artigo
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