The Development of Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 348-352, 2017.
Artigo
em Coreano
| WPRIM
| ID: wpr-165097
ABSTRACT
Non-alcoholic fatty liver disease (NAFLD) may be one of the important causes of cryptogenic hepatocellular carcinoma (HCC). NAFLD-related HCCs (NAFLD-HCCs) have the following clinical features high body mass index, deranged lipid profiles, diabetes mellitus, hypertension, and metabolic syndrome. Among them, obesity, diabetes mellitus, and high Fe contents in the liver are risk factors of developing HCC in patients with NAFLD. Inflammatory cytokines, adipokines, insulin like growth factor-I, and lipotoxicity are intermingled and may cross react with each other to develop HCC. Because there is no guideline for early detection of HCC in patients with NAFLD, NAFLD-HCCs tend to be greater in size and in advanced stages when detected compared with hepatitis virus-related HCCs. Therefore, there is an urgent need of a surveillance program for the early detection of HCC. Treatment of NAFLD-HCCs is not different from other causes-related HCCs. However, patients with NAFLD-HCCs have cardiovascular disease and other metabolic problems, which may complicate treatment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças Cardiovasculares
/
Índice de Massa Corporal
/
Fatores de Risco
/
Citocinas
/
Carcinoma Hepatocelular
/
Diabetes Mellitus
/
Adipocinas
/
Hepatopatia Gordurosa não Alcoólica
/
Hepatite
/
Hipertensão
Tipo de estudo:
Estudo de etiologia
/
Guia de Prática Clínica
/
Fatores de risco
/
Estudo de rastreamento
Limite:
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2017
Tipo de documento:
Artigo
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