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A lexicon for hepatocellular carcinoma surveillance ultrasonography: benign versus malignant lesions
Clinical and Molecular Hepatology ; : 57-65, 2017.
Artigo em Inglês | WPRIM | ID: wpr-165808
ABSTRACT
BACKGROUND/

AIMS:

To suggest a lexicon for liver ultrasonography and to identify radiologic features indicative of benign or malignant lesions on surveillance ultrasonography.

METHODS:

This retrospective study included 188 nodules (benign, 101; malignant, 87) from 175 at-risk patients identified during surveillance ultrasonography for hepatocellular carcinoma. We created a lexicon for liver ultrasonography by reviewing relevant literature regarding the ultrasonographic features of hepatic lesions. Using this lexicon, two abdominal radiologists determined the presence or absence of each ultrasonographic feature for the included hepatic lesions. Independent factors associated with malignancy and interobserver agreement were determined by logistic regression analysis and kappa statistics, respectively.

RESULTS:

Larger tumor size (odds ratio [OR], 1.12; 95% confidence interval [CI], 1.06-1.183; P<0.001), multinodular confluent morphology (OR, 7.712; 95% CI, 1.053-56.465; P=0.044), thick hypoechoic rim (OR, 5.878; 95% CI, 2.681-12.888; P<0.001), and posterior acoustic enhancement (OR, 3.077; 95% CI, 1.237-7.655; P=0.016) were independently associated with malignant lesions. In a subgroup analysis of lesions <2 cm, none of the ultrasonographic features were significantly associated with malignancy or benignity. Interobserver agreement for morphology was fair (κ=0.36), while those for rim (κ=0.427), echogenicity (κ=0.549), and posterior acoustic enhancement (κ=0.543) were moderate.

CONCLUSIONS:

For hepatic lesions larger than 2 cm, some ultrasonography (US) features might be suggestive of malignancy. We propose a lexicon that may be useful for surveillance US.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Acústica / Modelos Logísticos / Estudos Retrospectivos / Ultrassonografia / Carcinoma Hepatocelular / Fígado Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Fatores de risco / Estudo de rastreamento Limite: Humanos Idioma: Inglês Revista: Clinical and Molecular Hepatology Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Acústica / Modelos Logísticos / Estudos Retrospectivos / Ultrassonografia / Carcinoma Hepatocelular / Fígado Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Fatores de risco / Estudo de rastreamento Limite: Humanos Idioma: Inglês Revista: Clinical and Molecular Hepatology Ano de publicação: 2017 Tipo de documento: Artigo