Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein Activation
Biomolecules & Therapeutics
;
: 4-11, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-165942
ABSTRACT
Heterotrimeric G proteins are key intracellular coordinators that receive signals from cells through activation of cognate G protein-coupled receptors (GPCRs). The details of their atomic interactions and structural mechanisms have been described by many biochemical and biophysical studies. Specifically, a framework for understanding conformational changes in the receptor upon ligand binding and associated G protein activation was provided by description of the crystal structure of the β2-adrenoceptor-Gs complex in 2011. This review focused on recent findings in the conformational dynamics of G proteins and GPCRs during activation processes.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteínas de Ligação ao GTP
/
Proteínas Heterotriméricas de Ligação ao GTP
Idioma:
Inglês
Revista:
Biomolecules & Therapeutics
Ano de publicação:
2017
Tipo de documento:
Artigo
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