Marked Recovery From Paraquat-Induced Lung Injury During Long-Term Follow-up
The Korean Journal of Internal Medicine
; : 95-100, 2009.
Article
em En
| WPRIM
| ID: wpr-166675
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS: Paraquat-induced lung injury has been considered a progressive and irreversible disease. The purpose of this study was to report the long-term evolution of lung lesions in eight survivors with significant paraquat-induced lung injuries who could be followed-up for longer than 6 months. METHODS: We retrospectively examined high-resolution computed tomography and pulmonary function test of eight survivors with significant paraquat-induced lung injurys. RESULTS: High-resolution computed tomography revealed a predominant pattern of irregularly shaped consolidation with traction bronchiectasis at 1-2 months after paraquat poisoning, a mixed pattern of irregularly shaped consolidation and ground-glass opacity at 3-12 months, and a mixed pattern of consolidation, groundglass opacity, and honeycombing at 1-2 years. At 3-12 months after paraquat ingestion, the areas of consolidation had markedly decreased and the decreased lung volume had returned to normal. At 1-2 years after paraquat poisoning, the cystic changes had disappeared. At 2-3 years after paraquat poisoning, the decrease in forced vital capacity had greatly improved to the normal range. CONCLUSIONS: Recovery of nearly normal pulmonary structure and function may occur over several years following paraquat poisoning. Pulmonary function (both forced vital capacity and forced expiratory volume in 1 sec) evolved toward normal in the long-term survivors of paraquat poisoning with initial prominent lung injuries.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Paraquat
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Fibrose Pulmonar
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Fatores de Tempo
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Bronquiectasia
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Tomografia Computadorizada por Raios X
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Capacidade Vital
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Volume Expiratório Forçado
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Estudos Retrospectivos
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Seguimentos
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Sobreviventes
Tipo de estudo:
Observational_studies
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Prognostic_studies
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2009
Tipo de documento:
Article