Adalimumab Induced Acute Exacerbation of Rheumatoid Arthritis Related Interstitial Lung Disease
Journal of the Korean Geriatrics Society
;
: 134-137, 2013.
Artigo
em Coreano
| WPRIM
| ID: wpr-166886
ABSTRACT
A 69-year-old woman with 6 years history of seropositive rheumatoid arthritis (RA) and asymptomatic interstitial lung disease (ILD) began taking adalimumab for ongoing arthritis despite intakes of sulfasalazine and hydroxychloroquine for treatment. ILD progressed noticeably after 10 weeks of starting adalimumab. We discontinued adalimumab and added methylprednisolone 40 mg, and the patient's clinical findings gradually improved. The beneficial and adverse effects of tumor necrosis factor-alpha (TNF-alpha) inhibitors on RA associated ILD are unclear but this case reports adalimumab could abruptly exacerbate known ILD. We emphasize cautions on the use of adalimumab, one of the TNF-alpha inhibitors, in elderly RA patients with preexisting ILD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Artrite
/
Artrite Reumatoide
/
Sulfassalazina
/
Metilprednisolona
/
Fator de Necrose Tumoral alfa
/
Doenças Pulmonares Intersticiais
/
Anticorpos Monoclonais Humanizados
/
Adalimumab
/
Hidroxicloroquina
Limite:
Idoso
/
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Geriatrics Society
Ano de publicação:
2013
Tipo de documento:
Artigo
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