Ki67 Antigen as a Predictive Factor for Prognosis of Sinonasal Mucosal Melanoma
Clinical and Experimental Otorhinolaryngology
;
: 206-210, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-167131
ABSTRACT
OBJECTIVES:
Sinonasal mucosal melanoma is a rare and aggressive disease. The aim of this study was to analyze the clinical features of patients with sinonasal mucosal melanoma and to determine the role of Ki67 antigen as a predictor of prognosis in sinonasal mucosal melanoma.METHODS:
This was a retrospective case- series study at a single institution, an academic tertiary referral center. From 1995 to 2007, 27 patients with sinonasal mucosal melanoma were reviewed retrospectively, and the expression of Ki67 antigen was assessed by immunohistochemistry.RESULTS:
The overall 5-yr survival rate was 33.9%. No significant differences were observed in 5-yr survival according to age, sex, stage, or the presence of melanin. The rates of local failure, regional failure, and distant failure were 37.0%, 14.8%, and 11.1%, respectively. Patients with spindle or mixed cell types had better prognoses than those with other cell types. At a cut-off value of 35%, patients with lower Ki67 scores showed better survival than those with higher Ki67 scores.CONCLUSION:
The presence of spindle or mixed cell types may indicate a better prognosis than other cell types. Ki67 immunostaining may be a useful predictor of prognosis in patients with mucosal malignant melanoma of the sinonasal tract.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Seios Paranasais
/
Prognóstico
/
Imuno-Histoquímica
/
Taxa de Sobrevida
/
Estudos Retrospectivos
/
Centros de Atenção Terciária
/
Melaninas
/
Melanoma
/
Cavidade Nasal
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Clinical and Experimental Otorhinolaryngology
Ano de publicação:
2008
Tipo de documento:
Artigo
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