Therapy-related myeloid neoplasms in children and adolescents
Blood Research
;
: 242-248, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-167172
ABSTRACT
BACKGROUND:
This retrospective study aimed to characterize and analyze the outcome of therapy-related myeloid neoplasms (t-MNs) in children and adolescents.METHODS:
The medical records of 16 patients under 21 years of age at the time of t-MN diagnosis were reviewed.RESULTS:
The median patient age was 11.5 years (range, 1.6–20.4 yr). Twelve patients had therapy-related acute myeloid leukemia, 3 patients had myelodysplastic syndrome, and 1 patient had chronic myelomonocytic leukemia. The median latency period was 29 months (range, 11–68 mo). Fourteen patients had cytogenetic aberrations, 8 of whom had an 11q23 abnormality. Of the 13 patients treated with curative intent, 12 patients received myeloid-type induction therapy that led to complete remission (CR) in 8 patients. Nine patients underwent allogeneic transplantation; 4 patients did not undergo transplantation due to chemotherapy-related toxic death (N=3) or parental refusal (N=1). The 5-year overall survival and event-free survival of the 13 patients treated with a curative intent were 46.2% and 30.8%, respectively. For the 9 patients who underwent allogeneic transplantation, the 5-year event-free survival was 66.7%.CONCLUSION:
A significant proportion of young patients with t-MNs can experience long-term survival, and allogeneic transplantation plays a key role for attaining cure in these patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pais
/
Transplante Homólogo
/
Síndromes Mielodisplásicas
/
Leucemia Mielomonocítica Crônica
/
Leucemia Mieloide Aguda
/
Prontuários Médicos
/
Estudos Retrospectivos
/
Aberrações Cromossômicas
/
Intervalo Livre de Doença
/
Diagnóstico
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
Limite:
Adolescente
/
Criança
/
Humanos
Idioma:
Inglês
Revista:
Blood Research
Ano de publicação:
2016
Tipo de documento:
Artigo
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