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ATRA (all-trans-retinoic acid) Syndrome in Acute Promyelocytic Leukemia: Clinical and Radiologic Findings
Journal of the Korean Radiological Society ; : 339-343, 2001.
Artigo em Coreano | WPRIM | ID: wpr-16783
ABSTRACT

PURPOSE:

To describe the clinical and radiologic findings of all-trans-retinoic acid (ATRA) syndrome in acute promyelocytic leukemia. MATERIALS AND

METHODS:

Among 21 patients with acute promyelocytic leukemia who were treated with all-trans- retinoic acid between 1995 and 1998, we retrospectively evaluated the cases of four with ATRA syn-drome. Two were male and two were female, and their mean age was 58 years. The clinical and radiologic findings of chest radiography (n=4) and HRCT (n=1) were analyzed.

RESULTS:

Between seven and 13 days after ATRA treatment, dry cough, dyspnea and high fever developed in all patients. The WBC count in peripheral blood was significantly higher [2.9 -25.3(mean, 10.8)-fold] than before ATRA treatment, and in all patients, chest radiography revealed ill-defined consolidation and pleural effu-sion. Kerley 's B line (n=3) and hilar enlargement (n=3) were also seen, and in one patient, HRCT demonstrated septal line thickening. Among four patients treated with prednisolone and Ara-C,three recovered and one

CONCLUSION:

In acute promyelocytic patients treated with all-trans-retinoic acid, radiologic findings of ill-de-fined consolidation, pleural effusion, hilar prominence and Kerley 's B line may suggest ATRA syndrome. The early diagnosis of this will improve the patients' prognosis.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Derrame Pleural / Prognóstico / Tórax / Tretinoína / Prednisolona / Radiografia / Leucemia Promielocítica Aguda / Estudos Retrospectivos / Tosse / Diagnóstico Precoce Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Estudo de rastreamento Limite: Feminino / Humanos / Masculino Idioma: Coreano Revista: Journal of the Korean Radiological Society Ano de publicação: 2001 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Derrame Pleural / Prognóstico / Tórax / Tretinoína / Prednisolona / Radiografia / Leucemia Promielocítica Aguda / Estudos Retrospectivos / Tosse / Diagnóstico Precoce Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Estudo de rastreamento Limite: Feminino / Humanos / Masculino Idioma: Coreano Revista: Journal of the Korean Radiological Society Ano de publicação: 2001 Tipo de documento: Artigo