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KCHO-1, a novel herbal anti-inflammatory compound, attenuates oxidative stress in an animal model of amyotrophic lateral sclerosis
Journal of Veterinary Science ; : 487-497, 2017.
Artigo em Inglês | WPRIM | ID: wpr-16835
ABSTRACT
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective death of motor neurons in the central nervous system. The main cause of the disease remains elusive, but several mutations have been associated with the disease process. In particular, mutant superoxide dismutase 1 (SOD1) protein causes oxidative stress by activating glia cells and contributes to motor neuron degeneration. KCHO-1, a novel herbal combination compound, contains 30% ethanol and the extracts of nine herbs that have been commonly used in traditional medicine to prevent fatigue or inflammation. In this study, we investigated whether KCHO-1 administration could reduce oxidative stress in an ALS model. KCHO-1 administered to ALS model mice improved motor function and delayed disease onset. Furthermore, KCHO-1 administration reduced oxidative stress through gp91(phox) and the MAPK pathway in both classically activated microglia and the spinal cord of hSOD1(G93A) transgenic mice. The results suggest that KCHO-1 can function as an effective therapeutic agent for ALS by reducing oxidative stress.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Medula Espinal / Superóxido Dismutase / Camundongos Transgênicos / Sistema Nervoso Central / Neuroglia / Microglia / Estresse Oxidativo / Doenças Neurodegenerativas / Modelos Animais / Etanol Limite: Animais Idioma: Inglês Revista: Journal of Veterinary Science Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Medula Espinal / Superóxido Dismutase / Camundongos Transgênicos / Sistema Nervoso Central / Neuroglia / Microglia / Estresse Oxidativo / Doenças Neurodegenerativas / Modelos Animais / Etanol Limite: Animais Idioma: Inglês Revista: Journal of Veterinary Science Ano de publicação: 2017 Tipo de documento: Artigo