Differential expression of estrogen receptor α and progesterone receptor in the normal and cryptorchid testis of a dog / 한국실험동물학회지
Laboratory Animal Research
;
: 128-132, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-169020
ABSTRACT
Descending of the testes is an important process for spermatogenesis and cryptorchidism is one of the most relevant genital defects in dogs. In a previous study, we observed abnormal morphology and proliferation of Sertoli cells in a cryptorchid testis. In the present study, we investigated the expression of estrogen and progesterone receptors in the normal and cryptorchid testis of a dog. Elective orchidectomy was performed on the dog's abdominal right testis (undescended, cryptorchid) and scrotal left testis (descended, normal). In the normal testis, estrogen receptor α immunoreactivity was detected in Leydig cells alone, while estrogen receptor α immunoreactivity in the cryptorchid testis was significantly prominent in the Sertoli cells as well. In addition, progesterone receptor immunoreactivity in the control testis was detected in the spermatids, but was not detected in the cryptorchid testis. This result suggests that unilateral cryptorchidism causes increases of estrogen receptor α expression in Sertoli cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Progesterona
/
Células de Sertoli
/
Espermátides
/
Espermatogênese
/
Testículo
/
Orquiectomia
/
Receptores de Progesterona
/
Criptorquidismo
/
Estrogênios
/
Células Intersticiais do Testículo
Limite:
Animais
Idioma:
Inglês
Revista:
Laboratory Animal Research
Ano de publicação:
2016
Tipo de documento:
Artigo
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