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Epinephrine-induced lactic acidosis in orthognathic surgery: a report of two cases
Journal of the Korean Association of Oral and Maxillofacial Surgeons ; : 295-300, 2016.
Artigo em Inglês | WPRIM | ID: wpr-169366
ABSTRACT
Submucosal infiltration and the topical application of epinephrine as a vasoconstrictor produce excellent hemostasis during surgery. The hemodynamic effects of epinephrine have been documented in numerous studies. However, its metabolic effects (especially during surgery) have been seldom recognized clinically. We report two cases of significant metabolic effects (including lactic acidosis and hyperglycemia) as well as hemodynamic effects in healthy patients undergoing orthognathic surgery with general anesthesia. Epinephrine can induce glycolysis and pyruvate generation, which result in lactic acidosis, via β2-adrenergic receptors. Therefore, careful perioperative observation for changes in plasma lactate and glucose levels along with intensive monitoring of vital signs should be carried out when epinephrine is excessively used as a vasoconstrictor during surgery.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Plasma / Acidose Láctica / Epinefrina / Administração Tópica / Ácido Láctico / Ácido Pirúvico / Sinais Vitais / Cirurgia Ortognática / Glucose / Glicólise Tipo de estudo: Estudo diagnóstico Limite: Humanos Idioma: Inglês Revista: Journal of the Korean Association of Oral and Maxillofacial Surgeons Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Plasma / Acidose Láctica / Epinefrina / Administração Tópica / Ácido Láctico / Ácido Pirúvico / Sinais Vitais / Cirurgia Ortognática / Glucose / Glicólise Tipo de estudo: Estudo diagnóstico Limite: Humanos Idioma: Inglês Revista: Journal of the Korean Association of Oral and Maxillofacial Surgeons Ano de publicação: 2016 Tipo de documento: Artigo