Hypofractionated Stereotactic Radiation Therapy in Recurrent High-Grade Glioma: A New Challenge / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 37-44, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-169454
ABSTRACT
PURPOSE:
The aim of this study was to evaluate outcomes of hypofractionated stereotactic radiation therapy (HSRT) in patients re-treated for recurrent high-grade glioma. MATERIALS ANDMETHODS:
From January 2006 to September 2013, 25 patients were treated. Six patients underwent radiation therapy alone, while 19 underwent combined treatment with surgery and/or chemotherapy. Only patients with Karnofsky Performance Status (KPS) > 70 and time from previous radiotherapy greater than 6 months were re-irradiated. The mean recurrent tumor volume was 35 cm3 (range, 2.46 to 116.7 cm3), and most of the patients (84%) were treated with a total dose of 25 Gy in five fractions (range, 20 to 50 Gy in 5-10 fractions).RESULTS:
The median follow-up was 18 months (range, 4 to 36 months). The progression-free survival (PFS) at 1 and 2 years was 72% and 34% and the overall survival (OS) 76% and 50%, respectively. No severe toxicity was recorded. In univariate and multivariate analysis extent of resection at diagnosis significantly influenced PFS and OS (p 50 cm3), respectively (p=0.26).CONCLUSION:
In our experience, HSRT could be a safe and feasible therapeutic option for recurrent high grade glioma even in patients with larger tumors. We believe that a multidisciplinary evaluation is mandatory to assure the best treatment for selected patients. Local treatment should also be considered as part of an integrated approach.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Radioterapia
/
Análise Multivariada
/
Seguimentos
/
Radiocirurgia
/
Avaliação de Estado de Karnofsky
/
Intervalo Livre de Doença
/
Retratamento
/
Carga Tumoral
/
Diagnóstico
/
Tratamento Farmacológico
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Cancer Research and Treatment
Ano de publicação:
2016
Tipo de documento:
Artigo
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