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Treatment of Epilepsy Associated with Brain Tumors
Journal of the Korean Medical Association ; : 603-612, 2010.
Artigo em Coreano | WPRIM | ID: wpr-169781
ABSTRACT
Epilepsy associated with brain tumors (EABT) is a multi-faceted disease that both oncological and epileptological concerns should be taken into consideration. Usually, it is characterized by chronic drug-resistant epilepsy with a low-grade brain tumor in the cerebrum. However, the distinction of typical EABT and simple brain tumors with short-term epilepsy is obscure. We need a working formulation based on the patient's burden in both oncological and epileptological aspects. The diagnosis of EABT is straightforward, but the treatment should be more complex. Medical treatment with anticonvulsants aloneseems tobe anoutdated remedy for EABT because of the risk of tumor growth and malignant progression in some patients as well as the expected favorable seizure control after surgery. Surgical treatment of EABT has resulted in seizure-free state in about 80% of patients. Complete resection of the tumor is an important prognostic factor in seizure control and probably also in tumor control. Recently, many authors emphasized a lesion-directed surgery aimed at a complete tumor removal in EABT. However, in some patients, especially in patients with dual pathology, electrophysiological studies have to be thoroughly applied. For the treatment of EABT in the temporal lobe, more sophisticated surgical strategy is required. A lesionectomy saving the uninterrupted hippocampus could be applied for selected patients. Further research is strongly needed for better understanding and treatment of EABT and low-grade glioma.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Convulsões / Lobo Temporal / Encéfalo / Neoplasias Encefálicas / Epilepsia / Cérebro / Glioma / Hipocampo / Anticonvulsivantes Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Coreano Revista: Journal of the Korean Medical Association Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Convulsões / Lobo Temporal / Encéfalo / Neoplasias Encefálicas / Epilepsia / Cérebro / Glioma / Hipocampo / Anticonvulsivantes Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Coreano Revista: Journal of the Korean Medical Association Ano de publicação: 2010 Tipo de documento: Artigo