Comparison of the Effects of Nicorandil and Cocktail Solution to Prevent Radial Artery Spasm during Coronary Angiography
Korean Circulation Journal
; : 133-139, 2006.
Article
em Ko
| WPRIM
| ID: wpr-169969
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES: A radial artery spasm is one of the most common complications of coronary angiography during a transradial, causing considerable patient discomfort, which sometimes disturbs the procedure. This study was designed to evaluate the effects of nicorandil in the prevention of a radial artery spasm during coronary angiography. SUBJECTS AND METHODS: This was a randomized study to compare 4 mg of nicorandil and a 10 mL cocktail solution performed in 100 patients. Vasospasms of the radial artery, which were expressed as stenosis of the vessel diameter with a transradial approach and radial artery patency by pulse oximetry analysis one month later, were examined. RESULTS: Reductions in the systolic and diastolic blood pressures after administration of the spasmolytic agents were 15.8+/-11.8/ 8.4+/-8.0 and 20.5+/-13.6/6.7+/-6.2 in the for nicorandil and cocktail groups, respectively. Nicorandil induced a lesser decrease in the systolic BP than the cocktail, but without statistical significance (p=0.07). Both vasodilating agents showed a significant radial artery vasodilation following their intra-arterial administration (p<0.001 for all). The diameter of the radial artery showed a significant decrease in both groups following catheterization (p<0.05 for all). There were no significant differences between the two groups in terms of radial artery spasms (46 vs. 58% in nicorandil and cocktail groups, respectively, p=0.709). CONCLUSION: Nicorandil, with vasodilatory effects due to a dual mechanism was as effective as the cocktail solution in the vasodilation of the radial artery.
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Índice:
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Assunto principal:
Espasmo
/
Vasodilatação
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Oximetria
/
Cateterismo
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Angiografia Coronária
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Artéria Radial
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Constrição Patológica
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Nicorandil
/
Catéteres
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
Ko
Revista:
Korean Circulation Journal
Ano de publicação:
2006
Tipo de documento:
Article