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Association of Plasma Levels of Resistin with Subcutaneous Fat Mass and Markers of Inflammation but not with Metabolic Determinants or Insulin Resistance
Journal of Korean Medical Science ; : 695-700, 2009.
Artigo em Inglês | WPRIM | ID: wpr-170149
ABSTRACT
The aim of the present study was to investigate the relationship of plasma resistin levels with determinants of the metabolic syndrome (MetS) and anthropometric parameters in healthy Korean subjects. Plasma resistin levels were determined in 276 subjects. In subjects with MetS, the plasma resistin levels were not significantly increased compared to those without MetS (8.3+/-4.3 ng/mL vs. 8.5+/-3.6 ng/mL, respectively, P=0.84). In addition, the plasma resistin levels were not correlated with the body mass index, the waist circumference, homeostasis model assessment-insulin resistance (HOMA-IR), fasting plasma glucose or insulin levels. However, the plasma resistin levels were positively correlated with the abdominal subcutaneous fat (r=0.18, P<0.01) in all subjects and correlated with TNF alpha(r=-0.16, P<0.05) and hsCRP (r=0.15, P<0.05) in subjects without MetS but not with MetS. With multiple linear regression analysis, these linear associations remained to be significant. The results of this study show that plasma resistin levels in humans were not associated with markers of insulin resistance, obesity or other determinants of the MetS.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Glicemia / Proteína C-Reativa / Resistência à Insulina / Biomarcadores / Índice de Massa Corporal / Antropometria / Fator de Necrose Tumoral alfa / Síndrome Metabólica / Gordura Subcutânea / Resistina Tipo de estudo: Estudo prognóstico Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Glicemia / Proteína C-Reativa / Resistência à Insulina / Biomarcadores / Índice de Massa Corporal / Antropometria / Fator de Necrose Tumoral alfa / Síndrome Metabólica / Gordura Subcutânea / Resistina Tipo de estudo: Estudo prognóstico Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2009 Tipo de documento: Artigo