Proton Magnetic Resonance Spectroscopy in Patients with Neuro-Behcet's Disease / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 41-47, 2001.
Artigo
em Coreano
| WPRIM
| ID: wpr-17093
ABSTRACT
Magnetic resonance imaging (MRI)and computed tomography had been used to detect the neurologic lesions of the Behcet's disease.However,there are a number of cases which can not be detected by conventional imaging studies in neuro-Behcet's disease.To overcome this problem,magnetic resonance spectroscopy (MRS)has been introduced in several autoimmune diseases involving central nervous system such as neuropsychiatric lupus,but which was rarely performed in Behcet's disease.In the present study,we report two cases of neuro-Behcet's disease that showed normal MRI but abnormal proton MRS (1HMRS)findings.MRS in two cases revealed a reduction of the N-acetyl aspartate (NAA)/creatine (Cr)ratio in the substantia nigra and thalamus,respectively, which were the areas without abnormality on MRI,suggesting a functional defect of neurons in these areas.In a case with thalamic dysfunction,abnormal NAA/Cr ratio was normalized in parallel with clinical improvement after treatment with high-dose steroids and immuno-suppressive agents.These observa-tions suggest that MRS may be useful to early detect the functional abnormality in neuro-Behcet's disease and to monitor neurologic status after treatment with immuno-suppressive agents.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prótons
/
Doenças Autoimunes
/
Análise Espectral
/
Esteroides
/
Substância Negra
/
Imageamento por Ressonância Magnética
/
Espectroscopia de Ressonância Magnética
/
Sistema Nervoso Central
/
Ácido Aspártico
/
Neurônios
Limite:
Humanos
Idioma:
Coreano
Revista:
The Journal of the Korean Rheumatism Association
Ano de publicação:
2001
Tipo de documento:
Artigo
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