Toll-Like Receptor Ligands as Cancer Immunotherapeutics
Journal of Bacteriology and Virology
;
: 255-262, 2012.
Artigo
em Coreano
| WPRIM
| ID: wpr-170979
ABSTRACT
Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) expressed in a wide spectrum of cell types that recognize distinctive ligands and subsequently activate adaptive immune responses. TLR ligands are considered a promising target for development of immunomodulatory agents. Extensive clinical investigations are currently underway to develop TLR ligands-based non-specific immunostimulants and vaccine adjuvants. It has been well accepted that cancer cells develop a strategy to avoid host immune responses by producing inhibitory molecules. In addition, tumor-associated antigens are often not strong enough to induce effective anti-cancer immune responses. In this context, immunostimulants or adjuvants are critically required for more effective cancer immunotherapies. Here, we discuss recent progresses in the field of cancer immunotherapy under special emphasis on the TLR ligands as a component of immunostimulatory agents.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Adjuvantes Imunológicos
/
Receptores de Reconhecimento de Padrão
/
Receptores Toll-Like
/
Imunoterapia
/
Ligantes
Idioma:
Coreano
Revista:
Journal of Bacteriology and Virology
Ano de publicação:
2012
Tipo de documento:
Artigo
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