Effects of Add-on Ramelteon on Cognitive Impairment in Patients with Schizophrenia: An Open-label Pilot Trial
Clinical Psychopharmacology and Neuroscience
;
: 215-217, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-171397
ABSTRACT
OBJECTIVE:
This open-label study examined the effects of ramelteon on cognitive functions in 10 outpatients with schizophrenia.METHODS:
Ramelteon (8 mg/day) was administered to 10 patients with schizophrenia for six months. The verbal fluency test, Trail-Making Test, the Wisconsin Card Sorting Test, the Stroop Test, the Digit Span Distraction Test, Iowa Gambling Task, the Rey Auditory Verbal Learning Test were evaluated at baseline and 6 months after treatment with ramelteon.RESULTS:
Ramelteon improved significantly the scores of Rey Auditory Verbal Learning Test. Additionally, ramelteon exerted improvements in the verbal fluency and Iowa Gambling Task in 4 patients.CONCLUSION:
Ramelteon could be a potential therapeutic drug, in adjunctive treatment of learning and memory deficits seen in patients with schizophrenia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pacientes Ambulatoriais
/
Esquizofrenia
/
Aprendizagem Verbal
/
Wisconsin
/
Iowa
/
Teste de Stroop
/
Jogo de Azar
/
Aprendizagem
/
Transtornos da Memória
Limite:
Humanos
País/Região como assunto:
América do Norte
Idioma:
Inglês
Revista:
Clinical Psychopharmacology and Neuroscience
Ano de publicação:
2014
Tipo de documento:
Artigo
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