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Anti-inflammatory and antioxidant effects of umbelliferone in chronic alcohol-fed rats
Nutrition Research and Practice ; : 364-369, 2015.
Artigo em Inglês | WPRIM | ID: wpr-171620
ABSTRACT
BACKGROUND/

OBJECTIVES:

Inflammation is associated with various types of acute and chronic alcohol liver diseases. In this study, we examined whether umbelliferone (7-hydroxycoumarin, UF) ameliorates chronic alcohol-induced liver damage by modulating inflammatory response and the antioxidant system.

METHODS:

Rats were fed a Liber-Decarli liquid diet containing 5% alcohol with or without UF (0.05 g/L) for 8 weeks, while normal rats received an isocaloric carbohydrate liquid diet.

RESULTS:

Chronic alcohol intake significantly increased serum tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 levels and decreased interleukin 10 level; however, UF supplementation reversed the cytokines related to liver damage. UF significantly suppressed hepatic lipopolysaccharide binding protein, toll-like receptor 4 (TLR4), nuclear factor kappa B, and TNF-alpha gene expression increases in response to chronic alcohol intake. Masson's trichrome staining revealed that UF improved mild hepatic fibrosis caused by alcohol, and UF also significantly increased the mRNA expressions and activities of superoxide dismutase and catalase in liver, and thus, decreased lipid peroxide and mitochondrial hydrogen peroxide levels.

CONCLUSIONS:

The findings of this study indicate that UF protects against alcohol-induced liver damage by inhibiting the TLR4 signaling pathway and activating the antioxidant system.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Superóxido Dismutase / Fibrose / RNA Mensageiro / Proteínas de Transporte / Catalase / Expressão Gênica / Citocinas / NF-kappa B / Interleucina-6 / Fator de Necrose Tumoral alfa Limite: Animais Idioma: Inglês Revista: Nutrition Research and Practice Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Superóxido Dismutase / Fibrose / RNA Mensageiro / Proteínas de Transporte / Catalase / Expressão Gênica / Citocinas / NF-kappa B / Interleucina-6 / Fator de Necrose Tumoral alfa Limite: Animais Idioma: Inglês Revista: Nutrition Research and Practice Ano de publicação: 2015 Tipo de documento: Artigo