Homologous fibronectin enhances healing of excised wounds in rats
Journal of Korean Medical Science
;
: 197-205, 1991.
Artigo
em Inglês
| WPRIM
| ID: wpr-172065
ABSTRACT
In order to evaluate the effects of a topical application of homologous fibronectin on the healing of skin wounds, we made 2 excisional wounds on the back skin of each rat, applied ointment with or without fibronectin purified from citrated homologous plasma, and evaluated the effect according to wound size and microscopic findings. Excised lesions treated with carrier alone, but the difference was significant only in the early phase of wound healing, 2 and 3 days, according to wound size and microscopic changes. A significant decrease in wound size could be found in both groups, treated with ointment containing and not containing fibronectin, between day 4 and 9 when wound contraction was a major contributor to wound closure. Therefore it can be concluded that topical application of fibronectin has a beneficial effect on wound healing during its early phase, but no significant influence on wound contraction.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Bases para Pomadas
/
Ratos Endogâmicos
/
Pele
/
Cicatrização
/
Administração Tópica
/
Fibronectinas
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
1991
Tipo de documento:
Artigo
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