Regulation of MAPK Activity by Seizure-induced MKP-1 in Rat Hippocampus / 신경정신의학
Journal of Korean Neuropsychiatric Association
; : 873-880, 1999.
Article
em Ko
| WPRIM
| ID: wpr-172123
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES: Both electroconvulsive shock(ECS) and kainic acid-induced seizures activate mitogenactivated protein kinases(MAPKs)in rat hippocampus. They can also induce the expression of MAPK phosphatase-1(MKP-1)in rat hippocampus. MKP-1 is known as a specific MAPK deactivator. This study aimed to elucidate the role of MKP-1 in the deactivation of MAPKs in rat hippocampus. METHODS: In order to induce MKP-1 in the hippocampus, ECS was given to the rats. At the time points when MKP-1 was sufficiently induced, the second ECS was given to them and the subsequent phosphorylation or activation of MAPKs were measured in the hippocampus. A second group of rats were injected with kainic acid and the relationship between MKP-1 expression and MAPK phosphorylation was examined in their hippocampi. RESULTS: The expression of MKP-1 did not influence the phosphorylation or activation of MAPKs following ECS in rat hippocampus. Kainic acid-induced expression of MKP-1 did not significantly reduce the phosphorylation of MAPKs. CONCLUSION: MKP-1 did not play a significant role in the deactivation of MAPKs which were activated by ECS or kainic acid in rat hippocampus.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fosforilação
/
Convulsões
/
Eletrochoque
/
Hipocampo
/
Ácido Caínico
Limite:
Animals
Idioma:
Ko
Revista:
Journal of Korean Neuropsychiatric Association
Ano de publicação:
1999
Tipo de documento:
Article