Mean cell volumes of neutrophils and monocytes are promising markers of sepsis in elderly patients
Blood Research
;
: 193-197, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-172218
ABSTRACT
BACKGROUND:
Sepsis in elderly patients is a major cause of morbidity and mortality in the clinical setting. The aim of this study was to assess the diagnostic significance of volume conductivity scatter (VCS) parameters and to compare their reliability with that of inflammatory markers.METHODS:
Patients (N=85) were divided into 3 groups according to their clinical history and cultureresults:
control (N=29), localized infection (N=38), and sepsis (N=18). VCS parameters were obtained using a UniCel DxH 800 Coulter system. Cut-off values were established based on receiver operator characteristic (ROC) curves.RESULTS:
The mean volumes of neutrophils (MNV) and monocytes (MMV) were higher in the sepsis group than in the localized infection and control groups (P=0.000 for both). The mean cell conductivity and low median angle light scatter of neutrophils were lower in the sepsis group than in the localized infection and control groups (P=0.029 and P=0.022, respectively). With a cut-off of 156.5, MNV had a sensitivity of 83.3% and a specificity of 78% in predicting sepsis.CONCLUSION:
MNV and MMV, which can be obtained easily using an automated blood analyzer, may be promising hematologic parameters for distinguishing elderly individuals with and without sepsis and may help clinicians in the diagnosis of sepsis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Precursores de Proteínas
/
Calcitonina
/
Monócitos
/
Sensibilidade e Especificidade
/
Sepse
/
Índices de Eritrócitos
/
Luz
/
Neutrófilos
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Idoso
/
Humanos
Idioma:
Inglês
Revista:
Blood Research
Ano de publicação:
2013
Tipo de documento:
Artigo
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