Combination treatment with intrahepatic arterial infusion and intratumoral injection chemotherapy in patients with far-advanced hepatocellular carcinoma and arterioportal or arteriovenous shunts: preliminary results / 대한간학회지
The Korean Journal of Hepatology
;
: 120-129, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-172642
ABSTRACT
BACKGROUND/AIMS:
Combination treatment consisting of hepatic arterial infusion chemotherapy with epirubicin and cisplatin (HAIC-EC) and systemic infusion of low-dose 5-fluorouracil (5-FU) are sometimes effective against advanced hepatocellular carcinoma (HCC). However, there is no effective treatment for advanced HCCs with arterioportal shunts (APS) or arteriovenous shunts (AVS).METHODS:
We investigated a response and adverse events of a new combination protocol of repeated HAIC-EC and percutaneous intratumoral injection chemotherapy with a mixture of recombinant interferon-gamma (IFN-gamma) and 5-FU (PIC-IF) in patients with far-advanced HCCs with large APSs or AVSs.RESULTS:
There was a complete response (CR) for the large vascular shunts in all three patients and for all tumor burdens in two patients. Significant side effects were flu-like symptoms (grade 2) and bone marrow suppression (grade 2 or 3) after each cycle, but these were well-tolerated.CONCLUSIONS:
These results suggest that the combination of HAIC-EC and PIC-IF is a new and promising approach for advanced HCC accompanied by a large APS or AVS.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Infusões Intra-Arteriais
/
Angiografia
/
Epirubicina
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Tomografia Computadorizada por Raios X
/
Interferon gama
/
Cisplatino
/
Carcinoma Hepatocelular
/
Carga Tumoral
/
Fluoruracila
Tipo de estudo:
Guia de Prática Clínica
Limite:
Idoso
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The Korean Journal of Hepatology
Ano de publicação:
2011
Tipo de documento:
Artigo
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