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Maternal and neonatal effects of remifentanil used during induction of general anesthesia in preeclamptic patients undergoing cesarean delivery / 대한마취과학회지
Korean Journal of Anesthesiology ; : 62-68, 2009.
Artigo em Coreano | WPRIM | ID: wpr-172879
ABSTRACT

BACKGROUND:

Endotracheal intubation elicits cardiovascular and arousal responses. The present study was aimed to determine whether remifentanil affects these responses in patients with preeclampsia.

METHODS:

Thirty preeclamptic women who were scheduled to undergo cesarean delivery under general anesthesia were randomly assigned to receive either remifentanil 1 microgram/kg (n = 15) or saline (n = 15) before induction of anesthesia. Systolic arterial pressure (SBP), heart rate (HR) and bispectral index (BIS) value as well as plasma catecholamine concentrations were measured. Neonatal effects were assessed using Apgar score and umbilical cord blood gas analysis.

RESULTS:

Induction with thiopental caused a reduction in SBP and BIS (P < 0.01) in both groups. Following the tracheal intubation SBP and HR increased in both groups, the magnitude of which was lower in the remifentanil group. BIS values also increased, of which magnitude did not differ between the groups. Norepinephrine concentrations increased significantly following the intubation in the control, while remained unaltered in the remifentanil group. The neonatal Apgar scores (5 min), and umbilical gas values were similar in the two groups except for higher incidence of Apgar score < 7 at 1 min in the remifentanil group.

CONCLUSIONS:

Remifentanil 1 microgram/kg effectively attenuates hemodynamic and catecholamine but not BIS responses to tracheal intubation in preeclamptic patients undergoing cesarean delivery. However, remifentanil may cause mild neonatal depression and thus should be used when adequate facilities for neonatal resuscitation are available.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Índice de Apgar / Piperidinas / Plasma / Nível de Alerta / Pré-Eclâmpsia / Ressuscitação / Tiopental / Norepinefrina / Incidência / Depressão Tipo de estudo: Estudo de incidência / Estudo prognóstico Limite: Feminino / Humanos Idioma: Coreano Revista: Korean Journal of Anesthesiology Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Índice de Apgar / Piperidinas / Plasma / Nível de Alerta / Pré-Eclâmpsia / Ressuscitação / Tiopental / Norepinefrina / Incidência / Depressão Tipo de estudo: Estudo de incidência / Estudo prognóstico Limite: Feminino / Humanos Idioma: Coreano Revista: Korean Journal of Anesthesiology Ano de publicação: 2009 Tipo de documento: Artigo