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In utero hematopoietic stem cell therapy
Yonsei Medical Journal ; : 615-629, 2001.
Article em En | WPRIM | ID: wpr-173762
Biblioteca responsável: WPRO
ABSTRACT
In utero hematopoietic stem cell transplantation (IUHSCTx) is a promising approach for the treatment of a potentially large number of fetuses affected by congenital hematologic disorders. With technical advances in prenatal diagnosis and fetal intervention, the majority of these diseases can now be diagnosed early in gestation, allowing consideration of prenatal treatment. It, therefore, stands to reason that there is increasing interest in performing in utero hematopoietic stem cell transplantation at many centers around the world. Although the approach remains experimentally promising, expansion of clinical application will depend on improved understanding of the biological barriers to engraftment in the fetus as well as on the development of effective clinical strategies based on the hematopoietic biology of individual disorders.
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Texto completo: 1 Índice: WPRIM Assunto principal: Imunologia de Transplantes / Bioética / Fatores de Risco / Transplante de Células-Tronco Hematopoéticas / Doenças Fetais / Feto / Animais Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Yonsei Medical Journal Ano de publicação: 2001 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Imunologia de Transplantes / Bioética / Fatores de Risco / Transplante de Células-Tronco Hematopoéticas / Doenças Fetais / Feto / Animais Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Yonsei Medical Journal Ano de publicação: 2001 Tipo de documento: Article